Lawson Wilkins Pediatric Endocrine Society Banner
 
PES Newsletters
Seperator
Newsletter

In this Isssue:

Letter from President | Special Acknowledgement | 2011 Annual Meeting
Society Updates | Council and Committee Updates | 2010-2011 Award Winners
 

BOARD OF DIRECTORS

PRESIDENT
David B. Allen, MD
Madison, WI

PRESIDENT-ELECT
Janet Silverstein, MD
Gainesville, FL

SECRETARY
Peter Lee, MD
Hershey, PA

TREASURER
John Kirkland, MD
Houston, TX

PAST PRESIDENT
Dorothy Becker, MD
Pittsburgh, PA


AT LARGE
DIRECTORS

Mitchell Geffner, MD
Los Angeles, CA

Erica A. Eugster, MD
Indianapolis, IN

Stephen M. Rosenthal, MD
San Fransico, CA

PES MANAGEMENT


George K. Degnon, CAE
Executive Director

Christy McGinty Levine
Association Manager

Nicole Ritchey
Executive Assistant

PES National Office

6728 Old McLean Village Dr.
McLean, VA 22101
703-556-9222
Fax 703-556-8729

email: info@pedsendo.org

www.pedsendo.org

LETTER FROM THE PRESIDENT

Greetings! I hope that summertime has brought well-deserved relaxation for all. Fortunately, the PES Board, Councils, and Committees got a good running start in Vancouver, and have kept busy with several initiatives to keep PES growing in value for its members. It is my pleasure and privilege, on behalf of the PES leadership, to report on these important activities.

Thanks again for the opportunity to serve the Society. Please remember that a major objective of the PES Strategic Plan is to encourage and provide opportunities for engagement in PES activities to all members - so please contact us at www.pedsendo.org or info@pedsendo.org with your ideas of interest in getting involved.

Best Regards,
David B. Allen, MD
President, Pediatric Endocrine Society

Back to Top

Special Acknowlegment

Two years ago, PES member Scott Rivkees issued a clarion call about PTU-associated hepatoxicity and subsequently embarked on a scholarly investigation which engaged the PES D&T Committee, the Endocrine section of the AAP, the NIH and the FDA. The result of these efforts, the recent FDA black box warning about PTU hepatoxicity, will have a substantial beneficial impact on the care of children, as well as the treatment of adult- and pregnancy-related hyperthyroidism. Scott’s efforts to reveal PTU toxicity were recognized by MedScape as the #1 Endocrine Alert of 2009. PES takes great pride that this transformative event came from one of our own, and wishes to recognize, congratulate, and thank Dr. Scott Rivkees for this work. For more details, please visit the PES website at www.pedsendo.org

Back to Top

2011 Annual Meeting

Start to make plans to attend PAS-PES in Denver April 30-May 3, 2011! The PES Program Committee, chaired by Tom Wilson, is putting together a fantastic meeting for next spring. They were highly successful in placing several high value topics on the PAS program, including “Effects of chronic inflammation on growth and development, skeletal health, and body composition”, “New Genetic Mechanisms: Effects on Common Traits and Disease”, “Bone and Beyond: Pediatric Bone and Mineral Disorders in 2011”, and “Breakthroughs in the Molecular Pathogenesis of Congenital Thyroid Dysfunction”. In addition, a wealth of PES-specific programming will address hot topics in clinical pediatric endocrinology and career development and practice management sessions for early-in-career members and fellows. Occurring in such a beautiful and accesssible city, and with the planned addition of MOCE opportunities, PAS-PES 2011 promises to be a high quality experience for all.

Back to Top

Society Updates

A new name, new logo, and new website face for the Society:
This quarter began with a press release announcing the new name of the Pediatric Endocrine Society, along with an affirmation of the historical linkage of PES with Lawson Wilkins and our guiding mission statement.  By all accounts, this change in name has been well received worldwide. We have developed the new Society logo that accompanies this newsletter.


Journal affiliation:
We are excited to announce an affiliation of PES with the International Journal of Pediatric Endocrinology (http://www.hindawi.com/journals/ijpe/). This affiliation will provide PES members with regular email table of contents with free access via direct links to all IJPE articles and reduced rates for publishing articles. PES is also provided ample free space for prompt publication of Societysponsored guidelines, policy statements, and time-sensitive commentaries. We look forward to working with IJPE editor and PES member Scott Rivkees to make this journal affiliation a valuable step forward for the Society and its members.


Help with MOCE is on the way:
The MOCE Committee (Janet Silverstein and Robert Schwartz, co-Chairs) and other helpful PES members are working hard to facilitate the recertification process for PES members. We have partnered with AAP and ABP to create Part 4 QI modules relevant to pediatric endocrinology, including type 1 diabetes (JS and RS), congenital hypothyroidism (Rosalind Brown), obesity (Joyce Lee), CF-related diabetes (Sam Cassella). It is hoped that some or all of these will be available by next year. With regard to Part 2 (continuing learning) requirement, in addition to MOCE credit currently available through ABP website-posted review articles and AAP PREP Endocrinology, PES is planning to provide a session at our next annual meeting in Denver where articles will be reviewed and discussed for Part 2 credit. For more details, visit the PES MOCE Committee website at www.pedsendo.org.


PES Conflict of Interest (COI) guidelines:
The PES Board, with the help of a special COI task force, is carefully examining and revising the Society's approach to disclosing and managing potential COI. A basic premise is that the PES considers collaborative relationships with industry to be valuable to the mission of the Society, and is committed to manage these relationships responsibly and ethically. The PES is also pledged to leadership of the Society and its activities that is objective and unencumbered by conflicts of interest (COI). To manage potential COI in a consistent and ethical manner, by the end of 2010 PES will develop, make available to members, and adopt guidelines for PES-industry relations and potential individual COI with regard to financial support of the Society, its activities and products, and its leadership. Special thanks go out to members of the COI task force- Leona Cuttler, Scott Rivkees, Ericka Eugster, Paul Kaplowitz, and Wilma Rossi - for their expert and insightful work.

Back to Top

PES Council and Committee Updates

Public Policy Council: The PPC developed liaisons between the PES and the NIH Best Pharmaceutical Children’s Act (BPCA) program. This has led to the creation of a BPCA Endocrine Therapeutics Working Group that is now focusing on pediatric endocrine-related drug issues. The concern about potential propylthiouracil hepatoxicity in children brought to NIH and FDA attention by PPC, Chair Scott Rivkees has culminated in a “boxed-warning” by the FDA alerting practitioners about this risk and restrictions on PTU usage.
http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/
ucm209023.htm

Development Committee: PES has recently organized a Development Committee to raise funds for supporting the work of the organization, prompted by a climate of declining reimbursements and limitations on future Pharma contributions. Why should you get involved?

Perhaps one might answer with another question! What has your career as a pediatric endocrinologist meant to you? Pediatric endocrinologists take great satisfaction, both intellectual and emotional, in the acquisition of expertise in our rapidly changing field, and in using it to help the children we see every day in clinic. The PES plays a number of important roles in this process through its multiple educational, scientific, and advocacy activities.

The Society will be launching later this year both a campaign for annual membership contributions as well as a major gifts campaign for our more senior members with opportunities to make bequests or major gifts of appreciated stock or cash to our Legacy Fund which is dedicated to supporting future training grants for Clinical Scholars and Research Fellowships. We are asking PES members to look at the link on the PES website for information on Annual and Planned Giving: www.pedsendo.org/plannedgiving.cfm. Won't you please take just a moment to consider your personal legacy as a significant influence in the life of the children you have cared for, by including PES in your estate planning, and making an Annual Contribution to help the work of the Society? Watch for announcements on the annual planned giving opportunities and begin thinking now about how you will participate!

Thank you for your support!

Program Directors: The Program Directors are currently considering a proposal to standardize the date residents are offered positions in fellowship training programs. If passed, training programs that agree to this proposal will agree not to offer positions before a 'common offer date'. Details of this proposal will be sent to program directors for consideration at the end of July. Please be watching for these details as Program Directors will be asked to vote on this proposal and state whether or not they chose to participate.

Drug and Therapeutics Committee: For the 2010-2011 year, the PES Drug and Therapeutics Committee plans on maintaining the momentum of the productive 2009-2010 year. Guidelines on hyperglycemic hyperosmotic states and a review on the use of statins to treat hyperlipidemia associated with Type 1 DM will be published shortly in the Journal of Pediatrics and Pediatric Diabetes, respectively. The committee is currently working on a statement and review of issues surrounding growth hormone therapy and neoplasia, and a statement on the use of bariatric surgery in children. Additionally, the committee is working on a statement on the potential impact of endocrine disrupting chemicals on pediatric populations. This statement will be in collaboration with members of the European Society for Pediatric Endocrinology (ESPE).

Education Council:The Education Council was developed to oversee educational activities of the PES. These include the Board Review course, practice management materials, other courses as are deemed appropriate, and the PES website. It is our intent to maintain and upgrade the website to offer useful material for clinical updates of members as well as clinical materials for patient care and for referring physicians. In addition, the Education Council plans to coordinate activities with other PES groups including those involved with Maintenance of Certification activities, development of clinical consensus statements (D&T committee), obesity, and others in order to provide the highest level of information and education to our members and to other stakeholders in pediatric endocrinology as a discipline. The Council is presently developing a restructured Board Review Course. Shortly, subcommittees engaged in developing a clinical update and practice management course, collaborative MOCE/QI and MOCE/EQIP interactions, website-based fellow, patient and family, and pediatrician education will begin work.

Maintenance of Certification in Endocrinology: The MOCE Committee for the Part 4 QI requirement for recertification has been working with the AAP and with the ABP to put together modules that would be appropriate for pediatric endocrinologists. Proposals on Type 1 Diabetes and Congenital Hypothyroidism have been accepted by the AAP eQIPP committee. The AAP has been writing grants to attempt to secure the $150,000 funding to implement these modules but have not yet received funding.  Joyce Lee has volunteered to work with Paul Miles at the ABP to create an Obesity QI initiative. There is a template for this process in place and it is anticipated this will be available in the first half of next year.  It is a high priority for the ABP as it is relevant for both general pediatricians and all pediatric subspecialists. A conference call will be arranged in September 2010. Rosalind Brown and the congenital hypothyroid committee will have a similar discussion with Paul to determine the feasibility of developing a similar ABP QI initiative for newborn screening.  Sam Cassella has done an excellent job of collaborating with the CF Foundation (CFF) to add a quality improvement component for CFRD patients to the current CF Registry funded by the CFF.  This will be open to other endocrinologists who work with CF centers. Sam is in the process of obtaining ABP approval for this activity for Part 4 MOC credit.   Activities for Part 2 (continuing learning) MOCE credit are currently available through the AAP with ABP approved PREP Endocrinology  and through the ABP with posting of 5 Review articles on the ABP MOCE website.  PES is planning to provide  a session at upcoming meetings in which these articles can be discussed and Part 2 credit made available at the end of the session.

Back to Top

2010-2011 PES Award Winners

Research Fellowship Award Recipients

Andrew Calabria, MD
Glucagon-Like Peptide-1 and Post-prandial Hypoglycemia after Fundoplication
"We will be evaluating the role of glucagon-like peptide-1 (GLP-1) in the pathophysiology of late dumping syndrome/post-prandial hypoglycemia in children after Nissen fundoplication using the GLP-1 receptor antagonist, exendin-(9-39). We will also be evaluating the effects of exendin-(9-39) on glucose, insulin, glucagon, and gastric emptying in children (ages 6 months-18 years) who have had a Nissen fundoplication or similar gastric surgery."


Nursen Gurtunca, M.D.
IL-7 transduced dendritic cells as regulators of autoimmunity of diabetes mellitus
"The aim of our research project is to genetically engineer DC's to overexpress IL-7. Their efficacy will be tested in vitro and in vivo in an animal model. Our hypothesis is that diabetes-suppressive DC's that overexpress IL-7 will promote Treg cell homeostasis and improve their efficacy to prevent T1D and to reverse new-onset disease."


Jeanie Tryggestad, MD
Vascular Compliance and Endothelial Function in Children with Obesity and Type 2 Diabetes
"The goal of this project is to determine the independent effects of obesity and type 2 diabetes (T2DM) on vascular function, define how these conditions may modify the developmental pattern of vascular function during maturation, and begin to understand the mechanism driving the observed changes. In this project we test the hypothesis that obesity and T2DM adversely affect vascular function in youth. We will employ a cross-sectional approach to measure arterial elasticity and endothelial function in children 8-18 years, using noninvasive, reliable methods applicable to children. This study will lay the ground work for future studies aimed at therapeutic interventions to prevent adverse vascular changes in obesity and T2DM. We are particularly interested in the roles of exercise and diet and how lifestyle changes affect vascular function. The current project will also provide a foundation for future mechanistic work examining factors that lead to vascular change and how this may regulate vascular function changes as a result of lifestyle modification."


Yun Yan, MD
IGF-I Promotes Mesenchymal Stem Cell Bone Formation in Fracture Healing
"My research interest is tissue regeneration using stem cells, focusing on the role and mechanism of growth factors in bone."

2010-2011 Award Winners

Award Recipients

Mark Daniel DeBoer, MD, MSc., MCR
Improving endocrine-related outcomes in pre-pubertal colitis
"We study endocrine sequelae—including decreased linear growth, delayed puberty and decreased bone mineral density (BMD)—in the setting of inflammatory bowel disease, an important pediatric chronic disease. In this project we use a model of experimental colitis in mice to contrast the effects of two types of treatment: anti-inflammatory treatment with anti-TNF-a antibodies and appetite-stimulating treatment with an agonist of the hormone ghrelin. Both of these treatments have been shown to improve colitis disease severity, though their effects on endocrine sequelae are not known. Our hypothesis is that a large proportion of the endocrine sequelae in colitis is due to systemic inflammation and that treatment with anti-TNF-a antibodies will normalize endocrine outcomes of linear growth, pubertal timing and BMD more so than will treatment with ghrelin agonist. These experiments will provide early mechanistic data for future more detailed investigations regarding mechanisms of these endocrine sequelae."


Nancie MacIver, MD, PhD
Leptin as a regulator of T cell metabolism and function
"My research investigates the role of the hormone leptin in immune cell function. Leptin is secreted by adipocytes and is well known for its effects on appetite and weight regulation. Deficits in adipose tissue, as seen in malnutrition, lead to a deficiency of leptin, which plays a critical role in metabolic regulation as well as the development of immune function. Leptin-deficient individuals have a decrease in both total T and CD4 T cell number along with abnormal T cell function, making them more susceptible to intracellular infections and atopic disease, while administration of recombinant leptin protein reverses both the metabolic defects and immune abnormalities. The mechanisms by which leptin regulates lymphocyte number and function are not completely understood. Preliminary data suggest that leptin's effects on T cell function require activation of the T cell by signaling at both the T cell receptor (TCR) and co-stimulatory membrane protein CD28; that leptin activates the metabolic mediator AMP-activated protein kinase (AMPK) in lymphocytes; and that leptin is necessary for glucose uptake in activated cells. For these reasons, we hypothesize that the effects of leptin on lymphocyte number and function require full T cell stimulation and are mediated in part by leptin's effects on cellular metabolism."


Jennifer Yee, MD
Effect of SCD1 Inhibition on Adipocyte Differentiation in Newborn Rats Programmed to Develop Adult Obesity
"My research is on mechanisms of obesity, with a focus on the fatty acid synthesis pathways in adipogenesis and adipocyte differentiation. I am currently using stable isotope methodologies to study fatty acid de novo synthesis and desaturation in an animal model of prenatally programmed obesity. My long-term goal is to identify targets for prevention or treatment of obesity in the fatty acid synthesis pathways. I am collaborating with fetal programming investigator Mina Desai, PhD. My mentors are PES member W. N. Paul Lee, MD, and obstetrician & gynecologist/fetal programming researcher Michael Ross, MD."

Back to Top